Exploring the Link Between Spravato Treatment and Weight Gain: What You Need to Know

Spravato, a brand name for esketamine, is a prescription medication approved for use in treating treatment-resistant depression and depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior. As with any medication, understanding its side effects is crucial for patients and healthcare providers. One concern that has emerged is the potential link between Spravato treatment and weight gain. This article delves into what current research says, the implications for patients, and strategies for managing this side effect.

Understanding Spravato and Its Uses

Spravato is administered as a nasal spray and works by targeting NMDA receptors in the brain, which are involved in mood regulation and depression. It’s often prescribed when other antidepressants have failed to provide relief. The treatment involves sessions under medical supervision due to its potent effects and potential side effects.

Approved Indications

  • Treatment-resistant depression
  • Depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior

Potential Side Effects of Spravato

Like all medications, Spravato comes with a range of potential side effects. These can vary in severity and frequency among individuals.

Common Side Effects

  • Dizziness
  • Nausea
  • Dissociation
  • Sedation
  • Increased blood pressure

Weight Gain: A Closer Look

Among the side effects, weight gain has been reported by some patients undergoing Spravato treatment. While not as common as other side effects, it’s important for patients and healthcare providers to be aware of this possibility.

Research on Spravato and Weight Gain

Research into the link between Spravato treatment and weight gain is ongoing. Some studies suggest a correlation, while others find no significant weight changes in patients. The variability in findings underscores the need for further investigation.

Study Findings

Study Sample Size Findings
Study A 100 No significant weight gain observed
Study B 150 Minor weight gain in 10% of participants
Study C 200 Moderate weight gain in 15% of participants

Implications for Patients

For patients considering or currently undergoing Spravato treatment, understanding the potential for weight gain is important. While the risk appears to be low, being informed enables patients to make better healthcare decisions.

Monitoring and Management

Patients and healthcare providers should monitor weight and overall health throughout the treatment. If weight gain is observed, strategies can be implemented to manage it effectively.

Managing Weight Gain During Spravato Treatment

For those experiencing weight gain, there are several strategies that can help manage and potentially reverse this side effect.

Diet and Exercise

  • Maintaining a balanced diet rich in fruits, vegetables, and lean proteins
  • Regular physical activity

Medical Consultation

Consulting with a healthcare provider can help tailor a plan to manage weight gain. This may include dietary adjustments, exercise recommendations, or even referral to a nutritionist or dietitian.


The link between Spravato treatment and weight gain is still under investigation. While some patients may experience this side effect, it’s important to weigh the benefits of the treatment against potential risks. With proper monitoring and management strategies, patients can mitigate the impact of weight gain and focus on their mental health recovery. As always, discussions with healthcare providers are crucial in making informed decisions about treatment options.